background the aim of the present study was to investigate the effect of ginger and glibenclamide on oxidative stress markers. oxidative stress is caused by an unbalance between a relative overload of oxidants and depletion of antioxidants, as implicated in the pathogenesis of several chronic diseases, including atherosclerosis and diabetes mellitus. regarding the role of oxidative stress in th...

the aqueous extract of syzygium cumini (pulp) was investigated for its possible hypoglycemic and antioxidant potentials in streptozotocin (stz) induced diabetic wistar female rats. a single intraperitoneal injection of stz at a dose of 55 mg/kg body weight elevated the glucose levels more than 230 mg/dl after 3 days. treatment with the aqueous extract of syzygium cumini (pulp) at 100 mg/kg and ...

background: hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. the present study was designed to determine the role of gamma amino butyric acid b (gabab) receptor and l-arginine (l-arg) in gaba-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. methods: diabetes was induced by a single i.p. injection of strepto...

Background: This study aimed to investigate the possible apoptotic role of bortezomib (BMZ) on pancreatic islets streptozotocin (STZ)-induced diabetic rats.

abstract  introduction: diabetic rats display exaggerated hyperalgesic behavior in response to noxious stimuli that may resemble and model aspects of painful diabetic neuropathy in humans. this study was designed to investigate the effect of nigella sativum (ns) on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (stz)-induced diabetic rats.  methods: for this p...

use of medicinal plants for attenuation of hyperglycemia and restoration of lipids disorder to normal level is clinically very important. the aim of present study was to evaluate the effects of berberis integerrima bge. fruit aqueous extract (bifae) on blood glucose and lipid profile in streptozotocin (stz) - induced diabetic rats. the stz-induced diabetic rat were treated by fruit aqueous extr...

diabetes mellitus is a common endocrine disorder. anti-diabetic agents from natural and synthetic sources are available for the treatment of this disease. berberis integerrima is a medicinal shrub used in conventional therapy for a number of diseases. the aim of the present study was to investigate the effects of aqueous extract of berberis integerrima root (aebi) on some physiological paramete...

The objective of the present study was to evaluate α-glucosidase inhibitory and antidiabetic effects of Nopal water extract (NPWE) and Nopal dry power (NADP) in low-dose streptozotocin- (STZ-) induced diabetic rats fed a high-fat diet (HFD). The type 2 diabetic rat model was induced by HFD and low-dose STZ. The rats were divided into four groups as follows: (1) nondiabetic rats fed a regular di...

Abstract Objective This study was aimed at determining the nephroprotective potential of Sphaeranthus indicus Linn methanol extract (SME) against hyperglycemia and dyslipidemia in streptozotocin (STZ)-induced diabetic nephropathy (DNP) adult Wistar albino rats. Materials Methods Following STZ-induced diabetes, rats either sex with serum glucose level more than 250 mg/dL were chosen randomized i...

background: diabetes is a major public health problem. the development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. in this study, protective effects of sodium tungstate against stz-induced beta-cell damages were investigated. methods: sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic ra...